“Six to 10 million women in the United States receive hormone replacement therapy (HRT),” Hyder said in a press release. “We know that certain synthetic hormones used in HRT accelerate breast tumor development.”
Apigenin has been shown to delay or prevent this tumor development by blocking the supply of blood vessels to feed the tumors. However, it does not stop the initial formation of cancer cells within the breast.
The compound is most prevalent in parsley and celery, but can also be found in apples, oranges, nuts and other plant products. However, apigenin is not absorbed efficiently into the bloodstream, so scientists are unsure of how much can or should be ingested.
“We don’t have specific dosage for humans yet,” Hyder said. “However, it appears that keeping a minimal level of apigenin in the bloodstream is important to delay the onset of breast cancer.”
The study was published in Cancer Prevention Research.